Endocrine Abstracts

Background: Care of patients with diabetes should include an assessment of bone health. It is now clear that patients with type I DM have lower bone mineral density which may be manifested as osteopenia in growing skeleton and higher risk of fractures.Objective: To assess bone modelling through the measurement of bone formation and resorption indexes in diabetic children and their correlations with metabolic parameters.Methods: We ...

Introduction: 46 XX male syndrome generally presented as hypogonadotrophic hypogonadism.Case report: A 39-year-old man was referred to our clinic with a pituitary mass. He had a history of pituitary adenoma of 45×28×40 mm size which was found after his admission with right-sided vision loss at 2006. The hormonal analyses showed hypogonadotrophic hypogonadism without any excess hormone levels. A transcranial pituitary adenomectomy was performed....

Introduction: Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging, skin changes, gray hair, alopecia, muscle atrophy, osteoporosis, and cataracts and has a high frequency of association with rare neoplasms. In addition, some endocrinological abnormalities were manifested in this rare disease, such as hypogonadism, diabetes mellitus, hyperlipidemia. Atrophic changes of organs and systems such as skin, brain and genital organs were reported. H...

Introduction: Hashimoto’s thyroiditis (HT) is common autoimmune thyroid disorder and is predominantly the clinical expression of cell-mediated immunity leading to destruction of thyroid cells. Vitamin D plays a role in the regulation of immunity and cell proliferation. So, do the serum levels of vitamin D reduced in HT?Methods: We examined the medical records of the ‘Thyroid policlinic’ patients with or without HT. Vitamin D, thyroid autoa...

Introduction: Thyroid lymphoma is a rare disease. Furthermore, coincidence of extrathyroidal lymphoma is very rare.Case: A 69 years-old woman patient was admitted to the hospital with dyspnea, hoarse voice and swelling of throat for a month. In her history, she had been diagnosed as gastric lymphoma 6 years ago, while she was being investigated for upper gastrointestinal bleeding. Six cures of chemotherapy has been applied. She was not on follow up. In p...

Introduction: Vitamin D has a potentially beneficial role in insulin resistance, but there is a lack of evidence in elderly. We report preliminary results of an ongoing study that investigated the effect vitamin D replacement treatment (12 weeks) on insulin resistance and metabolic parameters in elderly people with normal glucose tolerance.Methods/design: The study’s eligibility criteria were body mass index <30.0 kg/m2, creatinine le...

Rhabdomyolysis is a characterized by muscle necrosis and release of intracellular muscle constituents into the circulation. Most cases are associated with a predisposing factor such as high dose statin therapy, diabetes, old age, female gender, renal failure or hypothyroidism.An 80-year-old woman presented with severe and generalized muscle pain. Her medical history included hypertension, congestive heart failure, chronic atrial fibrillation and a thy...

Objective: Diabetes mellitus (DM) is a complex disease that affects many systems. The most important cells of the immune system are lymphomononuclear (LMN) cells. Here, we aimed to evaluate the energy metabolism of LMN cells in patients with diabetes and impaired glucose tolerance.Methods: We measured LMN cell energy metabolism in patients with type 2 diabetes mellitus, impaired glucose tolerance (IGT) and healthy subjects. Cells were freshly isolated fr...

Paraoxonase is a high-density lipoprotein-bound antioxidant enzyme that inhibits atherosclerosis. Metabolic syndrome is a combination of several metabolic abnormalities and known to be related with increased cardiovascular events. The most important component of metabolic syndrome which have impact on oxidative stress is diabetes, the most severe form of disturbed carbohydrate metabolism. The effect of metabolic syndrome on oxidative stress and paroxonase-1 (PON-1) activity ha...

Metastatic infiltration of the adrenal glands is a common finding of malignancies, but few case reports showed primary adrenal insufficiency being the presenting manifestation of underlying malignant tumors. Here, we report a case of adrenal insufficiency secondary to metastases from lung adenocarcinoma.A 69-year-old man was admitted to emergency department with weakness, altered mental status, hypotension, fever and weight loss. He had 100 pack-year his...